Drug interactions
Empagliflozin-metformin + Moxifloxacin
Severity: Moderate
Empagliflozin-metformin and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients receiving antidiabetic drugs, particularly older adults and those with renal impairment. Moxifloxacin carries a lower risk than some others in the class but the warning applies.
What this interaction means in plain words
Empagliflozin-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release by blocking ATP-sensitive potassium channels, causing dysglycemia.
What to do
Monitor blood glucose during and shortly after the antibiotic course and educate the patient on symptoms of dysglycemia. Consider a non-fluoroquinolone antibiotic in patients with unstable glycemic control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Moxifloxacin?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients receiving antidiabetic drugs, particularly older adults and those with renal impairment. Moxifloxacin carries a lower risk than some others in the class but the warning applies.
How serious is the interaction between Empagliflozin-metformin and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and shortly after the antibiotic course and educate the patient on symptoms of dysglycemia. Consider a non-fluoroquinolone antibiotic in patients with unstable glycemic control.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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