Drug interactions
Empagliflozin-metformin + Perphenazine
Severity: Minor
Empagliflozin-metformin and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can raise blood glucose and impair glucose tolerance, although perphenazine has less metabolic effect than many atypical agents. Control with empagliflozin-metformin may be slightly weakened.
What this interaction means in plain words
Empagliflozin-metformin and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Antipsychotic effects on insulin secretion and sensitivity oppose antidiabetic action pharmacodynamically.
What to do
Monitor glucose when perphenazine is started or changed and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Empagliflozin-metformin with Perphenazine?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics can raise blood glucose and impair glucose tolerance, although perphenazine has less metabolic effect than many atypical agents. Control with empagliflozin-metformin may be slightly weakened.
How serious is the interaction between Empagliflozin-metformin and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when perphenazine is started or changed and adjust antidiabetic therapy if control worsens.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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