Drug interactions
Empagliflozin-metformin + Sirolimus
Severity: Moderate
Empagliflozin-metformin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus commonly causes hyperglycemia, insulin resistance and dyslipidemia, which can worsen glycemic control despite metformin and empagliflozin. Transplant recipients also often have reduced renal function, affecting drug safety.
What this interaction means in plain words
Empagliflozin-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR inhibition impairs insulin signaling and beta-cell function, opposing antidiabetic effects.
What to do
Monitor glucose, HbA1c and renal function and intensify antidiabetic therapy as needed. Reassess the suitability of metformin and empagliflozin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Sirolimus?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus commonly causes hyperglycemia, insulin resistance and dyslipidemia, which can worsen glycemic control despite metformin and empagliflozin. Transplant recipients also often have reduced renal function, affecting drug safety.
How serious is the interaction between Empagliflozin-metformin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, HbA1c and renal function and intensify antidiabetic therapy as needed. Reassess the suitability of metformin and empagliflozin if renal function declines.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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