Drug interactions
Empagliflozin-metformin + Tacrolimus
Severity: Moderate
Empagliflozin-metformin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus frequently causes post-transplant hyperglycemia and can impair renal function, weakening glycemic control and raising concern for metformin accumulation. Genital and urinary infections with empagliflozin are also a concern in immunosuppressed patients.
What this interaction means in plain words
Empagliflozin-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus impairs pancreatic beta-cell insulin secretion and is nephrotoxic, opposing antidiabetic effects.
What to do
Monitor glucose, renal function and signs of genitourinary infection, and adjust antidiabetic therapy as needed. Stop metformin if renal function declines substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-metformin and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-metformin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Tacrolimus?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus frequently causes post-transplant hyperglycemia and can impair renal function, weakening glycemic control and raising concern for metformin accumulation. Genital and urinary infections with empagliflozin are also a concern in immunosuppressed patients.
How serious is the interaction between Empagliflozin-metformin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, renal function and signs of genitourinary infection, and adjust antidiabetic therapy as needed. Stop metformin if renal function declines substantially.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
