Drug interactions
Emtricitabine + Etodolac
Severity: Moderate
Emtricitabine and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are eliminated renally, partly by tubular secretion, and may increase each other's exposure. Regular NSAID use can also reduce renal function, which raises emtricitabine levels.
What this interaction means in plain words
Emtricitabine and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Etodolac belongs to Musculoskeletal.
Why it happens
Competition for renal tubular secretion and NSAID-related reduction in glomerular filtration reduce emtricitabine clearance.
What to do
Prefer a non-NSAID analgesic when possible and monitor renal function if frequent or high-dose NSAIDs are needed. Adjust emtricitabine dosing to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Etodolac?
MediHelp rates the interaction as moderate. Emtricitabine and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are eliminated renally, partly by tubular secretion, and may increase each other's exposure. Regular NSAID use can also reduce renal function, which raises emtricitabine levels.
How serious is the interaction between Emtricitabine and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic when possible and monitor renal function if frequent or high-dose NSAIDs are needed. Adjust emtricitabine dosing to creatinine clearance.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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