Drug interactions
Emtricitabine + Ketoprofen
Severity: Moderate
Emtricitabine and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated by the kidney, and high-dose or multiple NSAID use alongside emtricitabine may raise levels of either drug. NSAIDs can also reduce renal function, further reducing emtricitabine elimination.
What this interaction means in plain words
Emtricitabine and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Ketoprofen belongs to Musculoskeletal.
Why it happens
Competition for active tubular secretion and NSAID-related reduction of glomerular filtration.
What to do
Consider non-NSAID analgesics, especially with high NSAID doses; otherwise monitor renal function and adjust emtricitabine dosing if creatinine clearance falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Ketoprofen?
MediHelp rates the interaction as moderate. Emtricitabine and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are eliminated by the kidney, and high-dose or multiple NSAID use alongside emtricitabine may raise levels of either drug. NSAIDs can also reduce renal function, further reducing emtricitabine elimination.
How serious is the interaction between Emtricitabine and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider non-NSAID analgesics, especially with high NSAID doses; otherwise monitor renal function and adjust emtricitabine dosing if creatinine clearance falls.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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