Drug interactions
Emtricitabine + Oxaprozin
Severity: Moderate
Emtricitabine and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can reduce renal function and compete for secretion. Regular NSAID use may increase emtricitabine exposure and renal risk.
What this interaction means in plain words
Emtricitabine and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAIDs reduce renal perfusion via prostaglandin inhibition and may compete for tubular secretion, decreasing emtricitabine clearance.
What to do
Prefer non-NSAID analgesics in patients on emtricitabine, particularly with reduced renal function. If an NSAID is needed, monitor serum creatinine and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Oxaprozin?
MediHelp rates the interaction as moderate. Emtricitabine and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can reduce renal function and compete for secretion. Regular NSAID use may increase emtricitabine exposure and renal risk.
How serious is the interaction between Emtricitabine and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-NSAID analgesics in patients on emtricitabine, particularly with reduced renal function. If an NSAID is needed, monitor serum creatinine and renal function.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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