Drug interactions
Emtricitabine + Sulindac
Severity: Moderate
Emtricitabine and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can reduce renal function. High-dose or prolonged NSAID use may therefore raise emtricitabine exposure and increase the chance of renal toxicity.
What this interaction means in plain words
Emtricitabine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Sulindac belongs to Musculoskeletal.
Why it happens
Possible competition for renal tubular secretion together with NSAID-related reduction in renal perfusion and glomerular filtration.
What to do
Prefer a non-NSAID analgesic where possible. If sulindac is needed, monitor serum creatinine and renal function, especially with high doses or pre-existing kidney disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Sulindac?
MediHelp rates the interaction as moderate. Emtricitabine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can reduce renal function. High-dose or prolonged NSAID use may therefore raise emtricitabine exposure and increase the chance of renal toxicity.
How serious is the interaction between Emtricitabine and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic where possible. If sulindac is needed, monitor serum creatinine and renal function, especially with high doses or pre-existing kidney disease.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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