Drug interactions
Enalapril + Everolimus
Severity: Major
Enalapril and Everolimus: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus taken with an ACE inhibitor raises the likelihood of angioedema, which can affect the face, tongue or airway and may be life-threatening. It may occur after prolonged therapy.
What this interaction means in plain words
Enalapril and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enalapril belongs to Cardiovascular; Everolimus belongs to Oncology.
Why it happens
Both drugs reduce bradykinin breakdown, leading to bradykinin accumulation and angioedema.
What to do
Tell patients to seek urgent help for swelling of the lips, tongue or throat. Stop enalapril and use another antihypertensive if angioedema develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Enalapril with Everolimus?
MediHelp rates the interaction as major. Enalapril and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Everolimus taken with an ACE inhibitor raises the likelihood of angioedema, which can affect the face, tongue or airway and may be life-threatening. It may occur after prolonged therapy.
How serious is the interaction between Enalapril and Everolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell patients to seek urgent help for swelling of the lips, tongue or throat. Stop enalapril and use another antihypertensive if angioedema develops.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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