Drug interactions
Enalapril + Pretomanid
Severity: Minor
Enalapril and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid may inhibit OATP1B3 and could modestly raise concentrations of substrates such as enalapril. The clinical significance is uncertain and likely small.
What this interaction means in plain words
Enalapril and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible inhibition of OATP1B3-mediated hepatic uptake, increasing enalapril exposure.
What to do
No dose change is routinely needed; monitor blood pressure and renal function if symptoms of excess ACE inhibitor effect appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Enalapril with Pretomanid?
MediHelp rates the interaction as minor. Enalapril and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid may inhibit OATP1B3 and could modestly raise concentrations of substrates such as enalapril. The clinical significance is uncertain and likely small.
How serious is the interaction between Enalapril and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor blood pressure and renal function if symptoms of excess ACE inhibitor effect appear.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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