Drug interactions
Enalapril + Tenapanor
Severity: Moderate
Enalapril and Tenapanor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenapanor reduces peak concentrations of enalapril and its active metabolite enalaprilat when given together. This may weaken blood pressure control.
What this interaction means in plain words
Enalapril and Tenapanor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Tenapanor belongs to Gastrointestinal Tract.
Why it happens
Inhibition of intestinal OATP2B1-mediated uptake reduces enalapril absorption.
What to do
Monitor blood pressure after starting tenapanor and increase the enalapril dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril and Tenapanor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Tenapanor
- Enalapril-hydrochlorothiazide + Tenapanor Moderate
- Rosuvastatin + Tenapanor Moderate
- Atorvastatin + Tenapanor Minor
- Bosentan + Tenapanor Minor
- Fexofenadine + Tenapanor Minor
- Fluvastatin + Tenapanor Minor
Frequently asked questions
Can I take Enalapril with Tenapanor?
MediHelp rates the interaction as moderate. Enalapril and Tenapanor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenapanor reduces peak concentrations of enalapril and its active metabolite enalaprilat when given together. This may weaken blood pressure control.
How serious is the interaction between Enalapril and Tenapanor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting tenapanor and increase the enalapril dose if needed.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
