Drug interactions
Rosuvastatin + Tenapanor
Severity: Moderate
Rosuvastatin and Tenapanor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenapanor, a gut-restricted agent, inhibits the intestinal uptake transporter OATP2B1, which contributes to rosuvastatin absorption. Rosuvastatin exposure may fall and lipid-lowering efficacy could be somewhat reduced.
What this interaction means in plain words
Rosuvastatin and Tenapanor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Tenapanor belongs to Gastrointestinal Tract.
Why it happens
Inhibition of intestinal OATP2B1 reduces rosuvastatin absorption.
What to do
Monitor lipid response and consider a higher rosuvastatin dose if the target is not met. Reassess when tenapanor is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Tenapanor
- Enalapril-hydrochlorothiazide + Tenapanor Moderate
- Enalapril + Tenapanor Moderate
- Atorvastatin + Tenapanor Minor
- Bosentan + Tenapanor Minor
- Fexofenadine + Tenapanor Minor
- Fluvastatin + Tenapanor Minor
Frequently asked questions
Can I take Rosuvastatin with Tenapanor?
MediHelp rates the interaction as moderate. Rosuvastatin and Tenapanor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenapanor, a gut-restricted agent, inhibits the intestinal uptake transporter OATP2B1, which contributes to rosuvastatin absorption. Rosuvastatin exposure may fall and lipid-lowering efficacy could be somewhat reduced.
How serious is the interaction between Rosuvastatin and Tenapanor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and consider a higher rosuvastatin dose if the target is not met. Reassess when tenapanor is started or stopped.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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