Drug interactions
Enalapril-hydrochlorothiazide + Tenapanor
Severity: Moderate
Enalapril-hydrochlorothiazide and Tenapanor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenapanor can lower the intestinal absorption of enalapril, reducing peak concentrations of enalapril and its active metabolite enalaprilat. This may weaken blood pressure control in patients on the combination tablet.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Tenapanor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Tenapanor belongs to Gastrointestinal Tract.
Why it happens
Tenapanor inhibits the intestinal uptake transporter OATP2B1, reducing enalapril absorption.
What to do
Monitor blood pressure when tenapanor is started or stopped and increase the enalapril dose if needed. Reassess the dose if tenapanor is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Tenapanor
- Enalapril + Tenapanor Moderate
- Rosuvastatin + Tenapanor Moderate
- Atorvastatin + Tenapanor Minor
- Bosentan + Tenapanor Minor
- Fexofenadine + Tenapanor Minor
- Fluvastatin + Tenapanor Minor
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Tenapanor?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Tenapanor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenapanor can lower the intestinal absorption of enalapril, reducing peak concentrations of enalapril and its active metabolite enalaprilat. This may weaken blood pressure control in patients on the combination tablet.
How serious is the interaction between Enalapril-hydrochlorothiazide and Tenapanor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when tenapanor is started or stopped and increase the enalapril dose if needed. Reassess the dose if tenapanor is discontinued.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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