Drug interactions
Fluvastatin + Tenapanor
Severity: Minor
Fluvastatin and Tenapanor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenapanor inhibits intestinal OATP2B1 and could reduce absorption of OATP2B1 substrates. Fluvastatin absorption may fall slightly, with uncertain impact on lipid lowering.
What this interaction means in plain words
Fluvastatin and Tenapanor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Tenapanor belongs to Gastrointestinal Tract.
Why it happens
Inhibition of intestinal OATP2B1 uptake by tenapanor reduces fluvastatin absorption.
What to do
Monitor lipid response and adjust the fluvastatin dose if efficacy is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Tenapanor
- Enalapril-hydrochlorothiazide + Tenapanor Moderate
- Enalapril + Tenapanor Moderate
- Rosuvastatin + Tenapanor Moderate
- Atorvastatin + Tenapanor Minor
- Bosentan + Tenapanor Minor
- Fexofenadine + Tenapanor Minor
Frequently asked questions
Can I take Fluvastatin with Tenapanor?
MediHelp rates the interaction as minor. Fluvastatin and Tenapanor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenapanor inhibits intestinal OATP2B1 and could reduce absorption of OATP2B1 substrates. Fluvastatin absorption may fall slightly, with uncertain impact on lipid lowering.
How serious is the interaction between Fluvastatin and Tenapanor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and adjust the fluvastatin dose if efficacy is inadequate.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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