Drug interactions
Bosentan + Tenapanor
Severity: Minor
Bosentan and Tenapanor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenapanor inhibits intestinal OATP2B1 and may reduce the absorption of OATP2B1 substrates. Bosentan exposure could be lowered, though the clinical significance is uncertain.
What this interaction means in plain words
Bosentan and Tenapanor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Tenapanor belongs to Gastrointestinal Tract.
Why it happens
Tenapanor inhibits intestinal OATP2B1 uptake, potentially reducing bosentan absorption.
What to do
Monitor clinical response to bosentan when starting tenapanor. Adjust therapy if efficacy declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Tenapanor
- Enalapril-hydrochlorothiazide + Tenapanor Moderate
- Enalapril + Tenapanor Moderate
- Rosuvastatin + Tenapanor Moderate
- Atorvastatin + Tenapanor Minor
- Fexofenadine + Tenapanor Minor
- Fluvastatin + Tenapanor Minor
Frequently asked questions
Can I take Bosentan with Tenapanor?
MediHelp rates the interaction as minor. Bosentan and Tenapanor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenapanor inhibits intestinal OATP2B1 and may reduce the absorption of OATP2B1 substrates. Bosentan exposure could be lowered, though the clinical significance is uncertain.
How serious is the interaction between Bosentan and Tenapanor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to bosentan when starting tenapanor. Adjust therapy if efficacy declines.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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