Drug interactions
Enalapril-hydrochlorothiazide + Fostemsavir
Severity: Minor
Enalapril-hydrochlorothiazide and Fostemsavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite inhibits OATP1B1/3, which may modestly raise levels of substrates. The relevance for enalapril is uncertain and likely small.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Fostemsavir belongs to Anti Virals.
Why it happens
Inhibition of OATP1B1/3 hepatic uptake transporters by temsavir.
What to do
Monitor blood pressure and renal function and adjust the enalapril dose if effects are exaggerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Fostemsavir?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Fostemsavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's active metabolite inhibits OATP1B1/3, which may modestly raise levels of substrates. The relevance for enalapril is uncertain and likely small.
How serious is the interaction between Enalapril-hydrochlorothiazide and Fostemsavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function and adjust the enalapril dose if effects are exaggerated.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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