Drug interactions
Enalapril-hydrochlorothiazide + Glimepiride
Severity: Moderate
Enalapril-hydrochlorothiazide and Glimepiride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and potentiate the glucose lowering effect of glimepiride, causing hypoglycemia in some patients. Hydrochlorothiazide may oppositely raise blood glucose and reduce control.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Glimepiride belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, adding to sulfonylurea effects, while thiazides impair glucose tolerance.
What to do
Monitor blood glucose, particularly after starting or adjusting the ACE inhibitor, and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enalapril-hydrochlorothiazide and Glimepiride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Glimepiride?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and potentiate the glucose lowering effect of glimepiride, causing hypoglycemia in some patients. Hydrochlorothiazide may oppositely raise blood glucose and reduce control.
How serious is the interaction between Enalapril-hydrochlorothiazide and Glimepiride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, particularly after starting or adjusting the ACE inhibitor, and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
