Drug interactions
Enalapril-hydrochlorothiazide + Isoproterenol
Severity: Moderate
Enalapril-hydrochlorothiazide and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol drives potassium into cells through beta-2 stimulation, and hydrochlorothiazide increases urinary potassium loss. Together they can produce clinically significant hypokalemia, raising arrhythmia risk, particularly in patients with cardiac disease.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Beta-2 mediated intracellular potassium shift combined with thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium and ECG when isoproterenol is given to patients on the thiazide combination. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Isoproterenol?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol drives potassium into cells through beta-2 stimulation, and hydrochlorothiazide increases urinary potassium loss. Together they can produce clinically significant hypokalemia, raising arrhythmia risk, particularly in patients with cardiac disease.
How serious is the interaction between Enalapril-hydrochlorothiazide and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG when isoproterenol is given to patients on the thiazide combination. Replace potassium as needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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