Drug interactions
Enalapril-hydrochlorothiazide + L-methylfolate
Severity: Minor
Enalapril-hydrochlorothiazide and L-methylfolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may slightly increase urinary loss of folate. This is rarely clinically significant in people with adequate dietary intake.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; L-methylfolate belongs to Miscellaneous.
Why it happens
Possible increased renal excretion of folate with thiazide diuretics; not firmly established.
What to do
No routine action is needed; assess folate status only if deficiency is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of L-methylfolate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with L-methylfolate?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may slightly increase urinary loss of folate. This is rarely clinically significant in people with adequate dietary intake.
How serious is the interaction between Enalapril-hydrochlorothiazide and L-methylfolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; assess folate status only if deficiency is suspected.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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