Drug interactions
Enalapril-hydrochlorothiazide + Leniolisib
Severity: Minor
Enalapril-hydrochlorothiazide and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3 and may increase exposure to substrates of these transporters. Enalaprilat, the active metabolite of enalapril, is not a clinically important OATP substrate, so a significant effect is unlikely.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake transporters may modestly raise exposure to substrates.
What to do
No dose adjustment is expected; monitor blood pressure after leniolisib is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Leniolisib?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits OATP1B1 and OATP1B3 and may increase exposure to substrates of these transporters. Enalaprilat, the active metabolite of enalapril, is not a clinically important OATP substrate, so a significant effect is unlikely.
How serious is the interaction between Enalapril-hydrochlorothiazide and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected; monitor blood pressure after leniolisib is started.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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