Drug interactions
Enalapril-hydrochlorothiazide + Methoxsalen
Severity: Moderate
Enalapril-hydrochlorothiazide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a recognized photosensitizer and methoxsalen is used to induce photosensitivity for phototherapy. Combined use may increase the risk of exaggerated phototoxic reactions such as severe sunburn or blistering.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of the two drugs.
What to do
Monitor for excessive erythema during phototherapy and adjust UV dose accordingly. Counsel patients on strict sun protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Methoxsalen?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a recognized photosensitizer and methoxsalen is used to induce photosensitivity for phototherapy. Combined use may increase the risk of exaggerated phototoxic reactions such as severe sunburn or blistering.
How serious is the interaction between Enalapril-hydrochlorothiazide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive erythema during phototherapy and adjust UV dose accordingly. Counsel patients on strict sun protection.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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