Drug interactions
Enalapril-hydrochlorothiazide + Nadolol
Severity: Minor
Enalapril-hydrochlorothiazide and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol and enalapril-hydrochlorothiazide have additive blood pressure lowering effects, which is often therapeutically intended but can cause hypotension or bradycardia. Thiazides may modestly affect glucose and lipids, and nadolol can mask hypoglycemia.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from beta blockade, ACE inhibition and diuresis.
What to do
Monitor blood pressure and heart rate at initiation and dose changes. Nadolol is renally cleared, so monitor renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Nadolol
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Nadolol?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol and enalapril-hydrochlorothiazide have additive blood pressure lowering effects, which is often therapeutically intended but can cause hypotension or bradycardia. Thiazides may modestly affect glucose and lipids, and nadolol can mask hypoglycemia.
How serious is the interaction between Enalapril-hydrochlorothiazide and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate at initiation and dose changes. Nadolol is renally cleared, so monitor renal function.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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