Drug interactions
Enalapril-hydrochlorothiazide + Phentolamine
Severity: Moderate
Enalapril-hydrochlorothiazide and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is an alpha-adrenergic blocker that causes vasodilation and hypotension. Together with enalapril-hydrochlorothiazide, the hypotensive response may be exaggerated, particularly after the first dose.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure lowering from alpha blockade and ACE inhibition/diuresis.
What to do
Monitor blood pressure closely during phentolamine administration and keep the patient supine if needed. Correct volume depletion before use and adjust doses as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Phentolamine?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is an alpha-adrenergic blocker that causes vasodilation and hypotension. Together with enalapril-hydrochlorothiazide, the hypotensive response may be exaggerated, particularly after the first dose.
How serious is the interaction between Enalapril-hydrochlorothiazide and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during phentolamine administration and keep the patient supine if needed. Correct volume depletion before use and adjust doses as required.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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