Drug interactions
Enalapril-hydrochlorothiazide + Piperacillin
Severity: Minor
Enalapril-hydrochlorothiazide and Piperacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piperacillin is cleared by the kidney through tubular secretion, and diuretic-induced volume depletion or reduced renal function could raise its levels. Thiazide diuretics may also lower potassium, which can be further reduced by piperacillin. Clinical effects are usually small.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Piperacillin belongs to Anti Bacterial.
Why it happens
Possible reduced renal clearance of piperacillin; additive hypokalemia risk.
What to do
Monitor serum potassium and renal function during piperacillin therapy and adjust the dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Piperacillin
- Piperacillin + Vancomycin Major
- Acetylsalicylic acid + Piperacillin Moderate
- Amikacin + Piperacillin Moderate
- Antithrombin alfa + Piperacillin Moderate
- Antithrombin iii + Piperacillin Moderate
- Argatroban + Piperacillin Moderate
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Piperacillin?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Piperacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Piperacillin is cleared by the kidney through tubular secretion, and diuretic-induced volume depletion or reduced renal function could raise its levels. Thiazide diuretics may also lower potassium, which can be further reduced by piperacillin. Clinical effects are usually small.
How serious is the interaction between Enalapril-hydrochlorothiazide and Piperacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function during piperacillin therapy and adjust the dose to renal function.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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