Drug interactions
Enalapril-hydrochlorothiazide + Prednisone
Severity: Moderate
Enalapril-hydrochlorothiazide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone can increase urinary potassium loss, adding to that of hydrochlorothiazide. Hypokalemia is more likely with higher doses and prolonged courses. Fluid retention and a rise in blood pressure from the corticosteroid may also reduce antihypertensive control.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from corticosteroid and thiazide effects.
What to do
Monitor serum potassium and blood pressure during prolonged or high-dose therapy and replace potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Prednisone?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone can increase urinary potassium loss, adding to that of hydrochlorothiazide. Hypokalemia is more likely with higher doses and prolonged courses. Fluid retention and a rise in blood pressure from the corticosteroid may also reduce antihypertensive control.
How serious is the interaction between Enalapril-hydrochlorothiazide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during prolonged or high-dose therapy and replace potassium if needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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