Drug interactions
Enalapril-hydrochlorothiazide + Probenecid
Severity: Minor
Enalapril-hydrochlorothiazide and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is secreted into the renal tubule by organic anion transporters, as is probenecid. Competition at this site may raise thiazide exposure, while probenecid's uricosuric effect can be opposed by thiazide-induced hyperuricemia.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for renal tubular organic anion secretion and opposing effects on urate handling.
What to do
Monitor blood pressure, electrolytes and serum uric acid. Increase the probenecid dose if urate control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Probenecid?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is secreted into the renal tubule by organic anion transporters, as is probenecid. Competition at this site may raise thiazide exposure, while probenecid's uricosuric effect can be opposed by thiazide-induced hyperuricemia.
How serious is the interaction between Enalapril-hydrochlorothiazide and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and serum uric acid. Increase the probenecid dose if urate control is lost.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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