Drug interactions
Enalapril-hydrochlorothiazide + Repaglinide
Severity: Minor
Enalapril-hydrochlorothiazide and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and so may blunt the glucose-lowering effect of repaglinide. The effect is usually small at low hydrochlorothiazide doses but can matter in poorly controlled diabetes.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazides impair insulin secretion and reduce insulin sensitivity, partly through hypokalemia.
What to do
Monitor blood glucose after starting or changing the thiazide dose and adjust the antidiabetic regimen if control worsens. Keep potassium in the normal range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Repaglinide?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and so may blunt the glucose-lowering effect of repaglinide. The effect is usually small at low hydrochlorothiazide doses but can matter in poorly controlled diabetes.
How serious is the interaction between Enalapril-hydrochlorothiazide and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the thiazide dose and adjust the antidiabetic regimen if control worsens. Keep potassium in the normal range.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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