Drug interactions
Enalapril-hydrochlorothiazide + Treprostinil
Severity: Moderate
Enalapril-hydrochlorothiazide and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a vasodilator and can add to the blood pressure lowering of enalapril and hydrochlorothiazide. Symptomatic hypotension may occur, especially after starting or raising the dose.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure reduction through different pathways.
What to do
Monitor blood pressure when starting or titrating treprostinil and reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Treprostinil?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a vasodilator and can add to the blood pressure lowering of enalapril and hydrochlorothiazide. Symptomatic hypotension may occur, especially after starting or raising the dose.
How serious is the interaction between Enalapril-hydrochlorothiazide and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or titrating treprostinil and reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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