Drug interactions
Enalapril-hydrochlorothiazide + Verapamil
Severity: Minor
Enalapril-hydrochlorothiazide and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and verapamil have additive blood pressure lowering effects, and the pharmacokinetic effect through tubular secretion is likely trivial. Excess hypotension is the main practical consideration, which is usually the intended therapeutic combination.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects; any renal secretion competition is of doubtful significance.
What to do
Monitor blood pressure and heart rate when combining or adjusting doses. No pharmacokinetic dose adjustment is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Verapamil?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide and verapamil have additive blood pressure lowering effects, and the pharmacokinetic effect through tubular secretion is likely trivial. Excess hypotension is the main practical consideration, which is usually the intended therapeutic combination.
How serious is the interaction between Enalapril-hydrochlorothiazide and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when combining or adjusting doses. No pharmacokinetic dose adjustment is usually needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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