Drug interactions
Encorafenib + Estradiol
Severity: Moderate
Encorafenib and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so its effect on estradiol exposure is unpredictable. Estrogen effect may be reduced, and hormonal contraception may be less reliable.
What this interaction means in plain words
Encorafenib and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Estradiol belongs to Endocrine.
Why it happens
Mixed inhibition and induction of CYP3A4 by encorafenib.
What to do
If estradiol is used for contraception, advise an additional non-hormonal method during therapy. Otherwise monitor for changes in estrogen effect and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Estradiol?
MediHelp rates the interaction as moderate. Encorafenib and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so its effect on estradiol exposure is unpredictable. Estrogen effect may be reduced, and hormonal contraception may be less reliable.
How serious is the interaction between Encorafenib and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If estradiol is used for contraception, advise an additional non-hormonal method during therapy. Otherwise monitor for changes in estrogen effect and adjust the dose accordingly.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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