Drug interactions
Encorafenib + Goserelin
Severity: Major
Encorafenib and Goserelin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib causes dose-dependent QT prolongation and goserelin may add to the effect through androgen suppression. Together they may raise the risk of torsades de pointes.
What this interaction means in plain words
Encorafenib and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Perform ECG and electrolyte checks before starting and periodically during therapy. Correct potassium and magnesium, and reduce or interrupt encorafenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Goserelin
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Goserelin?
MediHelp rates the interaction as major. Encorafenib and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib causes dose-dependent QT prolongation and goserelin may add to the effect through androgen suppression. Together they may raise the risk of torsades de pointes.
How serious is the interaction between Encorafenib and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG and electrolyte checks before starting and periodically during therapy. Correct potassium and magnesium, and reduce or interrupt encorafenib if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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