Drug interactions
Encorafenib + Hydroxychloroquine
Severity: Major
Encorafenib and Hydroxychloroquine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib causes dose-dependent QT prolongation, and hydroxychloroquine has a similar effect. Combined use raises the risk of clinically significant QT prolongation and torsades de pointes.
What this interaction means in plain words
Encorafenib and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Encorafenib belongs to Oncology; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive effects on cardiac repolarization lead to additive QT prolongation.
What to do
Avoid the combination where possible. If it is necessary, monitor the ECG and electrolytes at baseline and periodically, and reduce or interrupt encorafenib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Hydroxychloroquine?
MediHelp rates the interaction as major. Encorafenib and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib causes dose-dependent QT prolongation, and hydroxychloroquine has a similar effect. Combined use raises the risk of clinically significant QT prolongation and torsades de pointes.
How serious is the interaction between Encorafenib and Hydroxychloroquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is necessary, monitor the ECG and electrolytes at baseline and periodically, and reduce or interrupt encorafenib if the QTc becomes markedly prolonged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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