Drug interactions
Encorafenib + Modafinil
Severity: Moderate
Encorafenib and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so modafinil exposure may rise or fall unpredictably. This may result in either increased adverse effects or reduced wakefulness benefit.
What this interaction means in plain words
Encorafenib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib altering modafinil metabolism.
What to do
Monitor for loss of modafinil effect and for adverse effects such as insomnia and anxiety. Adjust modafinil dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Modafinil?
MediHelp rates the interaction as moderate. Encorafenib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so modafinil exposure may rise or fall unpredictably. This may result in either increased adverse effects or reduced wakefulness benefit.
How serious is the interaction between Encorafenib and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of modafinil effect and for adverse effects such as insomnia and anxiety. Adjust modafinil dose according to response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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