Drug interactions
Encorafenib + Nevirapine
Severity: Moderate
Encorafenib and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib is metabolized by CYP3A4 and itself modulates CYP3A4, while nevirapine is a CYP3A4 substrate and inducer. Concentrations of either drug may shift, with reduced encorafenib exposure and altered nevirapine levels possible.
What this interaction means in plain words
Encorafenib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Bidirectional CYP3A4 effects: nevirapine induction of encorafenib clearance, and encorafenib's mixed inhibition and induction of nevirapine metabolism.
What to do
Monitor for loss of oncologic efficacy and for nevirapine toxicity or loss of virologic control. Check HIV viral load periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Nevirapine?
MediHelp rates the interaction as moderate. Encorafenib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib is metabolized by CYP3A4 and itself modulates CYP3A4, while nevirapine is a CYP3A4 substrate and inducer. Concentrations of either drug may shift, with reduced encorafenib exposure and altered nevirapine levels possible.
How serious is the interaction between Encorafenib and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of oncologic efficacy and for nevirapine toxicity or loss of virologic control. Check HIV viral load periodically.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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