Drug interactions
Encorafenib + Oxycodone
Severity: Moderate
Encorafenib and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, and oxycodone is mainly cleared by CYP3A4. Oxycodone exposure may therefore rise or fall unpredictably, causing either opioid toxicity or loss of analgesia.
What this interaction means in plain words
Encorafenib and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Oxycodone belongs to Musculoskeletal.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters oxycodone metabolism.
What to do
Monitor pain control and signs of opioid excess such as sedation or slow breathing after starting or stopping encorafenib. Titrate the oxycodone dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Oxycodone?
MediHelp rates the interaction as moderate. Encorafenib and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, and oxycodone is mainly cleared by CYP3A4. Oxycodone exposure may therefore rise or fall unpredictably, causing either opioid toxicity or loss of analgesia.
How serious is the interaction between Encorafenib and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and signs of opioid excess such as sedation or slow breathing after starting or stopping encorafenib. Titrate the oxycodone dose to response.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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