Drug interactions
Encorafenib + Temsirolimus
Severity: Moderate
Encorafenib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so temsirolimus exposure may increase or decrease unpredictably. This could lead to either toxicity or reduced efficacy.
What this interaction means in plain words
Encorafenib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib altering temsirolimus metabolism.
What to do
Monitor for signs of temsirolimus toxicity and loss of response. Adjust the temsirolimus dose based on tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Temsirolimus?
MediHelp rates the interaction as moderate. Encorafenib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so temsirolimus exposure may increase or decrease unpredictably. This could lead to either toxicity or reduced efficacy.
How serious is the interaction between Encorafenib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of temsirolimus toxicity and loss of response. Adjust the temsirolimus dose based on tolerability.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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