Drug interactions
Encorafenib + Tramadol
Severity: Moderate
Encorafenib and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both induces and inhibits CYP3A4, so its effect on tramadol exposure is unpredictable. Induction may reduce formation of the active metabolite and analgesic effect, while inhibition may raise parent tramadol levels and the risk of seizures and serotonin toxicity.
What this interaction means in plain words
Encorafenib and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Encorafenib belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
Mixed CYP3A4 induction and inhibition by encorafenib altering tramadol metabolism.
What to do
Monitor for loss of analgesia and for adverse effects such as seizures or serotonergic signs. Adjust the tramadol dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Tramadol?
MediHelp rates the interaction as moderate. Encorafenib and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both induces and inhibits CYP3A4, so its effect on tramadol exposure is unpredictable. Induction may reduce formation of the active metabolite and analgesic effect, while inhibition may raise parent tramadol levels and the risk of seizures and serotonin toxicity.
How serious is the interaction between Encorafenib and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of analgesia and for adverse effects such as seizures or serotonergic signs. Adjust the tramadol dose according to response.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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