Drug interactions
Encorafenib + Vortioxetine
Severity: Minor
Encorafenib and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can both inhibit and induce CYP3A4, so its effect on vortioxetine exposure is unpredictable. Vortioxetine levels may rise, increasing adverse effects such as nausea, or fall, reducing antidepressant effect.
What this interaction means in plain words
Encorafenib and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Encorafenib belongs to Oncology; Vortioxetine belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib alters the partial CYP3A4-mediated metabolism of vortioxetine; vortioxetine is mainly metabolized by CYP2D6, so the net effect is likely small.
What to do
Monitor for tolerability and for loss of antidepressant response when starting or stopping encorafenib. Adjust the vortioxetine dose according to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Encorafenib with Vortioxetine?
MediHelp rates the interaction as minor. Encorafenib and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib can both inhibit and induce CYP3A4, so its effect on vortioxetine exposure is unpredictable. Vortioxetine levels may rise, increasing adverse effects such as nausea, or fall, reducing antidepressant effect.
How serious is the interaction between Encorafenib and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tolerability and for loss of antidepressant response when starting or stopping encorafenib. Adjust the vortioxetine dose according to clinical response.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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