Drug interactions
Enoxaparin + Lornoxicam
Severity: Major
Enoxaparin and Lornoxicam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam is an NSAID that inhibits platelets and can injure the gastric mucosa, markedly raising bleeding risk when given with enoxaparin. Gastrointestinal bleeding is the main concern.
What this interaction means in plain words
Enoxaparin and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enoxaparin belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from NSAID platelet inhibition and mucosal injury with enoxaparin's anti-Xa effect.
What to do
Avoid the combination where possible and use paracetamol or another non-NSAID analgesic. If unavoidable, use the lowest dose briefly, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Enoxaparin with Lornoxicam?
MediHelp rates the interaction as major. Enoxaparin and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lornoxicam is an NSAID that inhibits platelets and can injure the gastric mucosa, markedly raising bleeding risk when given with enoxaparin. Gastrointestinal bleeding is the main concern.
How serious is the interaction between Enoxaparin and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol or another non-NSAID analgesic. If unavoidable, use the lowest dose briefly, consider gastroprotection and monitor for bleeding.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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