Drug interactions
Enoxaparin + Pegaspargase
Severity: Moderate
Enoxaparin and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase lowers synthesis of several coagulation proteins, including fibrinogen and antithrombin, and can cause both bleeding and thrombosis. With enoxaparin, bleeding risk may rise, and reduced antithrombin may blunt heparin effect.
What this interaction means in plain words
Enoxaparin and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enoxaparin belongs to Cardiovascular; Pegaspargase belongs to Oncology.
Why it happens
Asparaginase-induced depletion of coagulation factors and antithrombin alters hemostasis in addition to the anticoagulant effect of enoxaparin.
What to do
Monitor for bleeding and follow fibrinogen, platelet count and anti-Xa levels where available. Adjust or hold enoxaparin if fibrinogen is markedly low or bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Enoxaparin with Pegaspargase?
MediHelp rates the interaction as moderate. Enoxaparin and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase lowers synthesis of several coagulation proteins, including fibrinogen and antithrombin, and can cause both bleeding and thrombosis. With enoxaparin, bleeding risk may rise, and reduced antithrombin may blunt heparin effect.
How serious is the interaction between Enoxaparin and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and follow fibrinogen, platelet count and anti-Xa levels where available. Adjust or hold enoxaparin if fibrinogen is markedly low or bleeding occurs.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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