Drug interactions
Entacapone + Ganaxolone
Severity: Moderate
Entacapone and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is sedating, and entacapone can cause somnolence and dizziness. Together they may increase daytime drowsiness and impair psychomotor performance.
What this interaction means in plain words
Entacapone and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entacapone belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for excess sedation and counsel patients to avoid driving or hazardous tasks until tolerance is established; reduce the ganaxolone dose if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Entacapone with Ganaxolone?
MediHelp rates the interaction as moderate. Entacapone and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is sedating, and entacapone can cause somnolence and dizziness. Together they may increase daytime drowsiness and impair psychomotor performance.
How serious is the interaction between Entacapone and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and counsel patients to avoid driving or hazardous tasks until tolerance is established; reduce the ganaxolone dose if sedation is troublesome.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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