Drug interactions
Entacapone + Lumateperone
Severity: Minor
Entacapone and Lumateperone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumateperone is cleared by CYP3A4, and inhibitors can raise exposure and increase somnolence and other adverse effects. Entacapone has not been shown to inhibit CYP3A4 meaningfully, so this effect is largely theoretical.
What this interaction means in plain words
Entacapone and Lumateperone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Lumateperone belongs to Central Nervous System.
Why it happens
Theoretical CYP3A4 inhibition reducing lumateperone clearance.
What to do
Monitor for sedation, orthostatic hypotension and other adverse effects. Dose reduction is not routinely needed unless a true CYP3A4 inhibitor is also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Entacapone and Lumateperone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Lumateperone
Frequently asked questions
Can I take Entacapone with Lumateperone?
MediHelp rates the interaction as minor. Entacapone and Lumateperone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumateperone is cleared by CYP3A4, and inhibitors can raise exposure and increase somnolence and other adverse effects. Entacapone has not been shown to inhibit CYP3A4 meaningfully, so this effect is largely theoretical.
How serious is the interaction between Entacapone and Lumateperone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and other adverse effects. Dose reduction is not routinely needed unless a true CYP3A4 inhibitor is also used.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
