Drug interactions
Entacapone + Mavacamten
Severity: Minor
Entacapone and Mavacamten: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized by CYP2C19 and CYP3A4, and inhibitors can increase exposure and the risk of reduced ejection fraction and heart failure. Entacapone is not an established inhibitor of these enzymes, so the interaction is theoretical.
What this interaction means in plain words
Entacapone and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Theoretical inhibition of CYP2C19 and CYP3A4 by entacapone.
What to do
Monitor echocardiographic LVEF and symptoms per mavacamten labeling. No empirical dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Entacapone and Mavacamten, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Entacapone with Mavacamten?
MediHelp rates the interaction as minor. Entacapone and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mavacamten is metabolized by CYP2C19 and CYP3A4, and inhibitors can increase exposure and the risk of reduced ejection fraction and heart failure. Entacapone is not an established inhibitor of these enzymes, so the interaction is theoretical.
How serious is the interaction between Entacapone and Mavacamten?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor echocardiographic LVEF and symptoms per mavacamten labeling. No empirical dose adjustment is needed.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
