Drug interactions
Entacapone + Methyldopa
Severity: Moderate
Entacapone and Methyldopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyldopa is a catechol compound and is partly metabolised by COMT, so entacapone may raise its levels. This can lead to increased hypotension or changes in heart rate. The clinical significance is likely modest.
What this interaction means in plain words
Entacapone and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entacapone belongs to Central Nervous System; Methyldopa belongs to Cardiovascular.
Why it happens
Entacapone inhibits catechol-O-methyltransferase, reducing the O-methylation of methyldopa.
What to do
Monitor blood pressure and heart rate when entacapone is started or stopped. Reduce the methyldopa dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Entacapone with Methyldopa?
MediHelp rates the interaction as moderate. Entacapone and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methyldopa is a catechol compound and is partly metabolised by COMT, so entacapone may raise its levels. This can lead to increased hypotension or changes in heart rate. The clinical significance is likely modest.
How serious is the interaction between Entacapone and Methyldopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when entacapone is started or stopped. Reduce the methyldopa dose if hypotension occurs.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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