Drug interactions
Entacapone + Palovarotene
Severity: Minor
Entacapone and Palovarotene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is a CYP3A substrate, and inhibitors can increase retinoid exposure and its toxicity, including mucocutaneous effects and premature growth plate closure. Entacapone is not an established CYP3A inhibitor, so the interaction is theoretical.
What this interaction means in plain words
Entacapone and Palovarotene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Palovarotene belongs to Miscellaneous.
Why it happens
Theoretical CYP3A inhibition by entacapone.
What to do
Monitor for retinoid adverse effects such as skin and mucosal dryness. Dose reduction is needed only if a true moderate CYP3A inhibitor is involved.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Entacapone with Palovarotene?
MediHelp rates the interaction as minor. Entacapone and Palovarotene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palovarotene is a CYP3A substrate, and inhibitors can increase retinoid exposure and its toxicity, including mucocutaneous effects and premature growth plate closure. Entacapone is not an established CYP3A inhibitor, so the interaction is theoretical.
How serious is the interaction between Entacapone and Palovarotene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for retinoid adverse effects such as skin and mucosal dryness. Dose reduction is needed only if a true moderate CYP3A inhibitor is involved.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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