Drug interactions
Entecavir + Ganciclovir
Severity: Minor
Entecavir and Ganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated by the kidney through filtration and active tubular secretion, so co-administration could raise concentrations of either one. Clinically important changes are not well documented, but risk is greater with reduced renal function.
What this interaction means in plain words
Entecavir and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Ganciclovir belongs to Anti Virals.
Why it happens
Possible competition for active renal tubular secretion.
What to do
Monitor renal function and adverse effects of both drugs, especially in renal impairment. Adjust doses of each drug to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ganciclovir
Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Canagliflozin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Dapagliflozin-metformin + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
Frequently asked questions
Can I take Entecavir with Ganciclovir?
MediHelp rates the interaction as minor. Entecavir and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are eliminated by the kidney through filtration and active tubular secretion, so co-administration could raise concentrations of either one. Clinically important changes are not well documented, but risk is greater with reduced renal function.
How serious is the interaction between Entecavir and Ganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adverse effects of both drugs, especially in renal impairment. Adjust doses of each drug to creatinine clearance.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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