Drug interactions
Entecavir + Hydrochlorothiazide-olmesartan
Severity: Minor
Entecavir and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated by glomerular filtration and tubular secretion, so drugs affecting renal function or secretion may raise its levels. Hydrochlorothiazide-induced volume depletion could have a similar effect, though the interaction is modest.
What this interaction means in plain words
Entecavir and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Possible reduced renal clearance through changes in renal function or tubular secretion competition.
What to do
Monitor renal function and adjust entecavir dose to creatinine clearance if function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Entecavir and Hydrochlorothiazide-olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Entecavir and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated by glomerular filtration and tubular secretion, so drugs affecting renal function or secretion may raise its levels. Hydrochlorothiazide-induced volume depletion could have a similar effect, though the interaction is modest.
How serious is the interaction between Entecavir and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adjust entecavir dose to creatinine clearance if function declines.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
