Drug interactions
Entecavir + Kanamycin
Severity: Moderate
Entecavir and Kanamycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral kanamycin is nephrotoxic, and declining renal function can raise entecavir exposure since it is renally cleared. Increased entecavir levels could occur if kidney injury develops.
What this interaction means in plain words
Entecavir and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aminoglycoside nephrotoxicity decreasing renal clearance of entecavir.
What to do
Monitor serum creatinine and kanamycin levels, and adjust entecavir dose or interval to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Kanamycin?
MediHelp rates the interaction as moderate. Entecavir and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral kanamycin is nephrotoxic, and declining renal function can raise entecavir exposure since it is renally cleared. Increased entecavir levels could occur if kidney injury develops.
How serious is the interaction between Entecavir and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and kanamycin levels, and adjust entecavir dose or interval to creatinine clearance.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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