Drug interactions
Entecavir + Metformin-sitagliptin
Severity: Moderate
Entecavir and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both entecavir and metformin are associated with lactic acidosis, so combined use may add to the risk. This is mainly relevant in renal impairment or liver disease.
What this interaction means in plain words
Entecavir and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Additive risk of lactic acidosis through mitochondrial effects (nucleoside analogue) and impaired lactate clearance (metformin); both renally eliminated.
What to do
Monitor renal function and watch for symptoms of lactic acidosis such as malaise, myalgia and dyspnea. Adjust doses for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Entecavir and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both entecavir and metformin are associated with lactic acidosis, so combined use may add to the risk. This is mainly relevant in renal impairment or liver disease.
How serious is the interaction between Entecavir and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for symptoms of lactic acidosis such as malaise, myalgia and dyspnea. Adjust doses for renal function.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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