Drug interactions
Entecavir + Tenofovir df
Severity: Minor
Entecavir and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are renally eliminated, and coadministration produced no meaningful change in their pharmacokinetics in studies. The combination is used in practice for hepatitis B, with attention to renal function.
What this interaction means in plain words
Entecavir and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Both drugs share renal elimination via filtration and tubular secretion, with a theoretical competitive effect.
What to do
No dose adjustment is needed with normal renal function. Monitor serum creatinine and phosphate periodically, and adjust doses if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Tenofovir df?
MediHelp rates the interaction as minor. Entecavir and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are renally eliminated, and coadministration produced no meaningful change in their pharmacokinetics in studies. The combination is used in practice for hepatitis B, with attention to renal function.
How serious is the interaction between Entecavir and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed with normal renal function. Monitor serum creatinine and phosphate periodically, and adjust doses if renal function declines.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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